Homeostatic Plasticity

Homeostatic synaptic plasticity

Neurons adapt their structural and functional properties in response to changes in network activity. However, despite these changes stability of neuronal networks must be assured. We study the cellular and molecular mechanisms, which control the ability of neurons to maintain stability, in order to better understand (and eventually augment) the ‘homeostatic resilience’ of neural networks under pathological conditions.

Selected Publications

Galanis C, Fellenz M, Becker D, Bold C, Lichtenthaler SF, Müller UC, Deller T, Vlachos A (2021) Amyloid-beta mediates homerostatic synapticity. J Neurosci. 41:5157-5172.

Lenz M, Kruse P, Eichler A, Straehle J, Beck J, Deller T, Vlachos A. (2021) All-trans retinoic acid induces synaptic plasticity in human cortical neurons. eLife. 2021. 10:e63026.

Strehl A, Galanis C, Radic T, Schwarzacher SW, Deller T, Vlachos A (2018) Dopamine modulates homeostatic excitatory synaptic plasticity of immature dentate granule cells in entorhino-hippocampal slice cultures. Front Mol Neurosci. 11:303.

Maggio N, Vlachos A° (2014) Synaptic plasticity at the interface of health and disease: new insights on the role of endoplasmic reticulum intracellular calcium stores. Neuroscience. 281C: 135-146.

Vlachos A°, Ikenberg B, Lenz M, Becker D, Reifenberg K, Bas Orth C, Deller T (2013). Synaptopodin regulates denervation-induced homeostatic synaptic plasticity. Proc Natl Acad Sci USA. 110: 8242-7.

Vlachos A*, Reddy-Alla S*, Papadopoulos T, Deller T, Betz H° (2013). Homeostatic regulation of gephyrin scaffolds and synaptic strength at mature hippocampal GABAergic postsynapses. Cereb Cortex. 23: 2700-2711.

Vlachos A°, Becker D, Jedlicka P, Winkels R, Roeper J, Deller T (2012). Entorhinal denervation induces homeostatic synaptic scaling of excitatory postsynapses of dentate granule cells in mouse organotypic slice cultures. PLoS One. 7: e32883.